Drug Discovery & Preclinical Development Expert

Drug discovery and preclinical development expert with strong focus on ADME/DMPK complemented with project and team leadership expertise with 10+ years in pharma and biotech industries

Hands-on expert with diverse translational areas (ADME/DMPK, structure-based-drug-design, MoA & target-deconvolution, protein production and biophysical interaction determination, LC-MS/MS bioanalysis)

Strategic advisory through all phases of drug discovery (from target-identification through IND-enabling and beyond)

Strong experience in regulatory interactions and filing as well as in outsourcing management

Strategic drug discovery & preclinical development advisory

DMPK subject‑matter expertise

Project leadership & cross‑functional management

Outsourcing & vendor management

Medical & scientific writing

Due‑diligence activities

Regulatory support

Protein production, biophysics, structure‑based drug design, bioanalysis, target deconvolution, and primary/secondary pharmacology

Represent DMPK in program teams and set up project‑specific DMPK needs

Interpret and elucidate pharmacokinetic behavior of drug candidates in animals, covering absorption, distribution, metabolism, and excretion

Provide recommendations on drug‑drug and drug‑food interactions

Investigate composition and effect of drug formulations on PK behavior in non‑clinical model

Coordinate with CROs for DMPK assay execution

Prepare DMPK sections for submission documents such as IBs, study reports, IND dossiers, and publications

Respond to DMPK queries from regulatory agencies

Oversee PBPK modeling and simulations

Plan, implement and manage early drug discovery projects

Define project scope, goals, deliverables, tasks and required resources

Lead druggability, Hit‑to‑Lead and Lead Optimization projects while managing cross‑functional teams

Manage budget, schedules and timelines; track deliverables and monitor progress

Present progress reports, identify barriers and propose solutions to stakeholders

Assess project results and provide recommendations aligned with business objectives

Facilitate issue‑oriented meetings, mediate conflicts and drive team success

Maintain project status records, databases and key information

Partner with management at all levels to ensure organizational alignment

ADME/DMPK representative on small‑molecule early discovery project teams

Influence project progression from Hit‑to‑Lead through Lead Optimization and nomination of development candidates

Partner with medicinal chemistry scientists to optimize structure‑property relationships

Instruct CROs to conduct investigative DMPK studies

Support drug discovery projects with activities such as drug‑target deconvolution, mode‑of‑interaction analysis, structure‑based drug design, and protein production

Analyze complex datasets and guide experimental direction

Support LC‑MS bio‑analytic laboratory operations

Deputy manager of a high‑throughput protein production and purification facility

Automated SLIC‑based high‑throughput cloning in multi‑host expression vector

Expression in bacterial, insect and mammalian cell cultures.

Isolation of high‑quality recombinant proteins for structural determination

Chip‑based high‑throughput analysis of protein and DNA

Conducted structural, biochemical, and cell‑biological studies of lipid‑binding proteins and their interaction with oncogenic and ciliary cargo proteins

Produced and purified recombinant proteins for X‑ray crystallography

Performed biophysical and biochemical assays to elucidate protein‑lipid interactions

Led scientific projects and supervised technicians and undergraduate students